The cold case: Are rhinoviruses perfectly adapted pathogens?

Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen.     

驾驶员最优预见跟踪仿真研究

预见信息的加入能使驾驶员提前感知跟踪目标未来变化,从而对飞机做出超前控制。研究了驾驶员最优预见跟踪控制算法,理论分析得出预见信息对预见控制的作用特点。最后通过人机系统模拟实验,验证了预见信息对驾驶员超前补偿的特性。     

Family I.3 lipase: bacterial lipases secreted by the type I secretion system

Based on the classification of bacterial lipolytic enzymes, family I.3 lipase is a member of the large group of Gram-negative bacterial true lipases. This lipase family is distinguished from other families not only by the amino acid sequence, but also by the secretion mechanism. Lipases of family I.3 are secreted via the well-known type I secretion system. Like most of proteins secreted via this system, family I.3 lipases are composed of two domains with distinct yet related functions. Recent years have seen an increasing amount of research on this lipase family, in terms of isolation, secretion mechanism, as well as biochemical and biophysical studies. This review describes our current knowledge on the structure-function relationships of family I.3 lipase, with an emphasis on its secretion mechanism. Received 18 April 2006; received after revision 3 July 2006; accepted 24 August 2006     

一种改进的实信号IFFT算法

由于重量轻、体积小、功耗低、功能强的小卫星工作在无人干预的低温 ,高辐射的空间环境中 ,因此星上计算机系统必须满足集成度高、寿命长、可靠性高、抗辐射能力强的要求。针对立体测绘小卫星的特点 ,我们设计了满足上述要求的集集中控制与分布控制优点于一身的星上计算机系统 ,对其可靠性进行了分析 ,并对提高其可靠性应采取的关键技术进行了简要的论述。     

差分放大器的理论与实验教学研究

讨论了差分式放大器教学中的几个典型问题,包括电路图的规范问题、小信号等效电路以及实验教学中的几个难点.     

机助数据采集与通用平差系统

PC-1500袖珍计算机是理想的野外数据采集工具,IBM系列微机又是比较普及的内业处理机,PC-1500与IBM又可以联机通讯.从而可达到从野外数据采集到内业数据处理的自动化.本文就控制测量的野外数据采集与内业数据处理作了一系列理论研究与实用试验,编制出一整套实用软件.可用于生产实际中.     

第二语言习得理论对我国英语教学产生的影响

第二语言习得理论的研究，加深了我们对语言学习过程的理解，也对我国英语教学产生了深远的影响。本文概述了第二语言习得理论研究成果对我国英语教学所产生的影响。     

交通信号灯智能控制系统设计与实现

研究了运用PLC技术的交通信号控制系统，用简洁的软硬件使其智能化程度更高。采用PLC与计算机之间的通讯链接技术，完成交通对象的复杂控制。并运用模糊控制原理，将人的控制经验及推理过程纳入系统自动控制当中，使车辆行驶和道路导航实现智能化。     

非对称信息条件下假冒伪劣现象的发生机制

近年来，假冒伪劣已经成为日常生活中见怪不怪的现象，严重地危害了经济和社会的健康发展。本文仅从信息经济学的角度对近年来假冒伪劣现象泛滥成灾的发生机制进行深层分析，并相应地提出了构建有效的信号传递机制进行治理。     

雷达辐射源信号双谱二次特征提取方法

现有的双谱特征提取方法可以满足信号分类识别，但是出现了交叉项、平凡双谱以及特征维数过高等一些问题。针对以上问题，提出一种双谱二次特征提取方法，将双谱转化为灰度图像，以灰度值表示双谱幅度；再利用图像处理技术提取双谱二次特征，提取出能够表征辐射源信号双谱图像纹理信息的灰度共生矩阵特征集；将该特征集与Hu-不变矩特征集进行对比实验。仿真结果表明：该方法具有更好的分类识别性能，对于CW、LFM和NLFM信号的平均识别率均达90%以上。